Bioactive Small Molecules
Medchemexpress LLC PRRSV/CD163-IN-1 | 560995-89-3 | 98.28% | 557.62 | 25 MG
PRRSV/CD163-IN-1 is a PRRSV/CD163 inhibitor that can inhibit the interaction between the PRRSV glycoprotein (GP2a or GP4) and the CD163-SRCR5 domain. It can be used for the research of porcine reproductive and respiratory syndrome (PRRS).
- Inhibits protein-protein interaction between PRRSV GP4 glycoprotein and CD163-SRCR5 domain
- Well-tolerated by porcine alveolar macrophages (PAMs) at concentrations below 25 μM
- Inhibits PRRSV infection of PAMs in a dose-dependent manner
- Significantly inhibits infection caused by both type I and type II PRRSV strains
Medchemexpress LLC Boc-Pip-butyn | 1346153-07-8 | 95.79% | 237.34 | 25 MG
Boc-Pip-butyn is an alkyl/ether-based PROTAC linker that functions as a click chemistry reagent. It incorporates an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing azide groups.
- It is an alkyl/ether-based PROTAC linker.
- It serves as a click chemistry reagent.
- It contains an alkyne group.
- It can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.
- It is intended for research use only.
Cayman Chemical 1-Myristoyl-2-hydroxy-sn-glycero-3-PE, Purity: ≥98%, CAS: 123060-40-2, 5 mg
A naturally occurring lysophospholipid; induces transient increases in intracellular calcium in PC12 cells; serum levels are elevated in patients with malignant breast cancer compared to healthy controls
Medchemexpress LLC 2-Ethyl-6-methylaniline-d13 | 1219794-93-0 | 98.6% | 148.29 | 100 MG
2-Ethyl-6-methylaniline-d13 is the deuterium labeled 2-Ethyl-6-methylaniline. It is for research use only.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Deuteration has the potential to affect the pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Octanedioic acid,1-methyl ester | 3946-32-5 | 188.22 | 1 ML
Monomethyl octanoate (also known as Suberic acid monomethyl ester) is an ester product primarily utilized as a PROTAC linker. It can be employed in the synthesis of PROTACs, specifically DDD2 (HY-176261), for research purposes.
- Ester product
- Functions as a PROTAC linker
- Suitable for the synthesis of PROTACs, including DDD2
- High purity for reliable research
- Molecular formula: C9H16O4
- Molecular weight: 188.22
- Appears as colorless to light yellow
- Solid below 17°C, liquid above 19°C
- Classified as ketones, aldehydes, and acids
- Derived from an endogenous metabolite
Cayman Chemical BPN14770, Purity: ≥98%, CAS: 1606974-33-7, 1 mg
A PDE4D inhibitor; selectively inhibits dimeric PDE4DS129D and PDE4DS54D over wild-type dimeric PDE4D, dimeric PDE4DS133D, and monomeric PDE4D2 (IC50s = 7.8, 7.4, 1,018, 2,013, and 127 nM, respectively); enhances novel object discrimination in mice from 0.3-30 mg/kg; decreases hyperarousal and increases social interaction time, indicating anxiolytic-like activity, nesting, and marble-burying behavior in the Fmr1-/- mouse model of fragile X syndrome at 0.3 mg/kg
Medchemexpress LLC 4-acetamidobutanoic acid-d3 (N-acetyl GABA-d3) | 00-00-0 | MFCD00020552 | 148.17 g/mol | C6H8D3NO3 | 1 MG
4-acetamidobutanoic acid-d3 (N-acetyl GABA-d3) is the deuterated analog of 4-acetamidobutanoic acid, supplied for use as an isotopically labeled internal standard in quantitative analytical workflows. Formula C6H8D3NO3, molecular weight 148.17 g/mol. Supplied in milligram quantities for use in NMR, GC-MS, and LC-MS.
- Isotopically labeled internal standard for quantitative analysis.
- Provides a clear mass shift for accurate LC-MS and GC-MS quantitation.
- Compatible with NMR for deuterium-based tracing and structural studies.
- Supplied in small, precisely measured amounts for analytical assays.
- Useful as a tracer in metabolic and pharmacokinetic investigations.
Cayman Chemical Ganoderic Acid D, Purity: ≥97%, CAS: 108340-60-9, 5 mg
An oxygenated triterpenoid; inhibits glucose uptake and lactate production at 50-200 µM and decreases pyruvate and acetyl-coenzyme A production at 100 and 200 µM in HT-29 and SW620 colon cancer cells; increases protein levels of SIRT3 in HT-29 and SW620 cells; cytotoxic to HepG2, HeLa, and Caco-2 cells (IC50s = 0.14, 0.18, and 0.02 µg/ml, respectively)
Medchemexpress LLC Phospho-AMPK alpha 1 (Ser496) Antibody | 100 UL
This rabbit-derived, non-conjugated IgG polyclonal antibody specifically targets phosphorylated AMPK alpha 1 at Ser496. Intended for research use only, it serves as a valuable tool for detecting modification-specific phosphorylation, crucial for studies in cellular energy metabolism.
- Host: Rabbit
- Clonality: Polyclonal
- Species reactivity: Human
- Molecular weight: 64 kDa (predicted and observed)
- Immunogen: Synthetic phosphopeptide (Ser496 of Human AMPKα1)
- Applications: Western blot (WB), Immunohistochemistry (IHC-P), Immunocytochemistry/Immunofluorescence (ICC/IF)
- Purity: Affinity purified
- Formulation: Supplied in 1*PBS (pH 7.3), 50% glycerol, 0.5% BSA, 0.02% sodium azide
- Storage: Store at -20°C for 1 year, avoid freeze/thaw cycles
- Shipping: With blue ice
- Detects phosphorylated protein at Ser496
- Supports research in cellular energy metabolism
Medchemexpress LLC ERD03 | 1377897-01-2 | 99.98% | 339.43 | 100 MG
ERD03 is a potent disruptor of the EXOSC3-RNA interaction (Kd of 17±7 μM). It induces a PCH1B-like phenotype in zebrafish embryos and is useful for neurological disorder disease research. For storage, solid form should be kept at 4°C under nitrogen. In solvent, store at -80°C for 6 months or -20°C for 1 month, both under nitrogen.
- Potent disruptor of EXOSC3-RNA interaction (Kd of 17±7 μM)
- Induces PCH1B-like phenotype in zebrafish embryos
- Useful for neurological disorder disease research
- Inhibits G-rich RNA and EXOSC3 binding (~18% inhibition at 50 μM)
- Causes significant spinal curvature in zebrafish embryos (at 50 μM for 5 days)
- Upregulates ataxin1b mRNA (~6-fold at 50 μM)
- Induces atrophy of the zebrafish cerebellum
TARGETMOL CHEMICALS INC BMS CCR2 22 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. BMS CCR2 22 is a potent and selective antagonist of CCR2 with calcium flux IC50 of 18 nM chemotaxis IC50 of 1 nM and binding IC50 of 5.1 nM. purity: 98%
Medchemexpress LLC STS-E412 | 1609980-39-3 | 99.7% | 318.76 | C15H15ClN4O2 | 1 ML
STS-E412 is a selective activator of the tissue-protective erythropoietin receptor complex (EPOR and CD131), supplied as a 10 mM solution in DMSO for preclinical research in neurodegenerative disease and organ protection.
- Selective activator of tissue-protective EPO receptor
- Supplied as a 10 mM solution in DMSO, 1 mL
- High reported purity (99.7%)
- Molecular weight 318.76; formula C15H15ClN4O2
- Solubility: readily soluble in DMSO; in vivo formulation possible in 10% DMSO/90% corn oil
- Recommended storage: powder -20°C (long term) or 4°C; in solvent -80°C (preferred) or -20°C
Medchemexpress LLC N-Desethyl amodiaquine dihydrochloride (Standard) | 79049-30-2 | 1 MG
N-Desethyl amodiaquine dihydrochloride (Standard) is the analytical standard of N-Desethyl amodiaquine dihydrochloride. This product is intended for research and analytical applications. It is the biologically active metabolite of Amodiaquine and acts as an antiparasitic agent. This compound inhibits Plasmodium falciparum strains V1/S and 3D7 with IC50 values of 97 nM and 25 nM, respectively, and can be utilized for malaria research.
- Analytical standard
- Intended for research and analytical applications
- Biologically active metabolite of Amodiaquine
- Antiparasitic agent
- Inhibits Plasmodium falciparum strains V1/S and 3D7
- Can be used for malaria research
Medchemexpress LLC Trans-cyclohexane-1,2-diol | 1460-57-7 | MFCD00066430 | 99.7% | 116.16 | 1 ML
Trans-cyclohexane-1,2-diol | 1460-57-7 | MFCD00066430 | 99.7% | 116.16 | 1 ML
Medchemexpress LLC GSK2879552 dihydrochloride | 1902123-72-1 | 99.8% | 437.40 | 1 ML
GSK2879552 dihydrochloride | 1902123-72-1 | 99.8% | 437.40 | 1 ML